If you choose User profiles as a data source, no additional configuration of data source is needed, just go through the wizard until the end. Unless you want to configure dotted-line managers or configure assistants.
To understand how Org Chart communicates with the User profiles service, read this article.
In the Advanced data source settings, you can enable displaying vacancies. They are stored in a separate SharePoint list. The list will be created automatically at specified Vacancies list URL.
Note
Go to the next available data source Excel / CSV.